In episode 14 of the current series, Nev and Max came across 19-year old Keyonnah - who believed she was in an online relationship with the Young Money star.
According to the teenager, they struck up a romance after she sent Bow Wow a message via his Facebook page - and they began to chat online.
However, the Outta My System hitmaker was never available to video chat, causing concern for Nev and the rest of the Catfish team.
It later turned out that 'Bow Wow' was actually Atlanta-Based female rapper Dee Pimpin.
The BET 106 & Park host has since responded to the shock episode in an online video, where he states: "I feel honoured. It's dope and it's flattering when someone wants to be you… That's crazy, but I like it. It's free promo for myself."
The 26-year old continued: "Quite frankly, I would actually like to meet them both.
"Here's a message for the girl who got Catfished and to the person who was pretending to be me: I am opening the door here at my house and I'm inviting you to come to 106 & Park to sit down so I can ask you two some questions. We gotta do it on my time, though. On our network, on our show."
Bow Wow also had some advice for those who are currently having an online romance, concluding: "Everybody out there Internet cyber dating, just make sure you know who you’re talking to. I guess that’s the best thing I can say.
"That’s why I don’t really do things like that. I don’t talk to women over the Internet." With a brief pause, he added with a laugh: "I’m lying! I do it all the time!"
Do you want MTV's help to meet your online lover? Catfish: The TV Show is coming to the UK in 2014!