According to Now magazine, the Girls Aloud beauty is hoping to hit the studio with Britney after asking producer JR Rotem - who both Cheryl and Spears have worked with - for the pop princess' number.
Speaking of a possible Chezza and Brit hook-up, a pal of the Fight For This Love singer told the mag: "She'd love to do a duet with Britney for her next album."
The reports come after Cole's bodyguard Craig Balkam claimed that Cheryl wanted to make friends with Britney, telling The Mirror: "She used to talk about Britney Spears. She kept saying that she wanted to help Britney."
He added: "She thought she could become like a big sister to her and make her normal again after all her crazy behaviour."