The X Factor USA presenter also claimed that Kris - whose marriage toKim Kardashianlasted just 72 days - is "fame hungry", when she appeared on Watch What Happens Live on US telly.
"He's, in my opinion, delusional," she said. "He's delusional. I don't know why he's asking for anything - he got married just like she got married. He's fame hungry, in my opinion, and wants money. I don't know - I just think everything he's doing, it's just gross to me.
"I've never had a divorce - I don't know why they would take so long, especially when you have pre-nups and you were married for 72 days... I think it's been over a year since they filed for divorce. I don't know why when there's all this legality already set in place before the marriage, why it takes so long."
Humphries has been trying to get a marriage annulment on the grounds of fraud - and Khloe pointed out that the divorce has now lasted "five times as long" as the marriage.
She continued: "I have never run into the Hump since, I don't know, New York days I guess. I don't know. I don't know the last time I've seen him but I've never run into him.
Khloe, whose hubby Lamar Odom is also a basketball player, continued: "Whenever [Lamar] plays the Nets they play against each other, but they don't talk - I've asked Lamar. I go to every Clipper game and I've been there, and it's like we don't know each other. It's very awkward. It's like, the tension.
"But it's also weird because everyone in the arena is looking to see if there's going to be some sort of conflict or something, and I think we pay more attention to not saying anything, because everyone is staring."