“If I was a lesbian, you would be my girlfriend," outspoken Mel said during a hosting stint on Australian radio station 2Day FM.
“Why thank you, Mel. Let's lez it out a little bit!" Khloe shot back jokingly.
The reality TV star – who is currently going through a divorce with hubby LamarOdom – also spoke out about the difficult phase in her life.
"It's definitely not anything I'm through. I'm going through it, but I'm not through it," she explained.
"It's really hard to watch yourself on TV. It's definitely different in that the world has to watch, too. It’s definitely not the easiest thing to do, but it's what my life is."
When Mel B’s co-host MerrickWatts remarked that youngest Kardashians Kylie and KendallJenner had transformed on the show, going from tweens to sex symbols almost overnight, Khloe jumped in: “Ok relax on the ‘sex symbols’! They’re still under 18. Well one is 18,” she clarified.
“They’re really good girls and they don’t take themselves so seriously either,” she added. “You can't in this industry.”