The Fast & Furious actor, who was tragically killed in a car accident last November, will be remembered at the ceremony - which is set to take place at Los Angeles' Nokia Theater.
MTV president, Stephen Friedman, said of the tribute: "Paul Walker was a role model for the MTV audience since the very beginning of his too-short career.
"Our audience grew up with him, from Varsity Blues to the Furious franchise. He was a movie star, but one they could relate to. Paul's humanity and kindness clearly showed through every role."
He added: "We're honoured to be able to spend a moment in this year's Movie Awards to celebrate him."
MTV Movie Awards executive producer Garrett English also told Associated Press: "Well I think we are just really happy and honoured that they were willing to allow us to celebrate him in someway on the show. And his family and friends were willing to have that happen.
"He's been such a big part of the channel, what the channel's audience has been about. He's been such a big part of our show in the past that if felt really right to us and we're just really happy and honorued that they were willing to allow us to do something for him on the show."