When asked about the possibility of the Call My Name singer being successful Stateside, Perez replied: "Do I think Cheryl Cole will ever make it big in America?
"I think there are a lot of factors at play there, but the biggest one is if she is willing to devote the time necessary to break as a musical artist in America."
He continued: "Unlike the UK, we don't have national radio here that's relevant - it's a lot harder to get your songs on the radio across the United States.
"So it takes a lot of going to the stations and shaking hands, performing small shows."
Hilton added: "That's actually something that Cher Lloyd did do and did it quite well, and Cher has had a great 2012 in America."
As well as offering Cheryl some advice, Hilton went on to reveal what he is looking forward to in 2013 - stating he would prefer not to write about troubled actress Lindsay Lohan so much.
Perez said: “I want to be talking less about Lindsay Lohan, and that hopefully she doesn’t die.”
Watch MTV News on the hour every hour on MTV - Sky Channel 126 and Virgin Channel 134