The 14-time Grammy winner will play Manchester Cathedral as part of the free, ticketed live music event in association with Manchester City Council.
The show marks Keys' first UK performance of songs from her new album Girl On Fire - which is due for release on 26th November - as well as some old classics.
Speaking of the gig, Alicia said: "All of the love and work I’ve poured into Girl On Fire has been for moments like this —when I’m able to travel the world and share the experience of performing my favourite songs with my family across the globe.
“I’m so excited to be a part of MTV Crashes Manchester and to celebrate music in such an inspiring and historic setting.”
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