The pair, who play Daryl and Merle Dixon respectively, will be featured in The Walking Dead: Survival Instinct - which takes place before the events depicted in the AMC series.
The game sees the argumentative brothers fighting zombies as they cross the Georgia countryside toward Atlanta.
"Our goal is to shape Daryl authentically, chronicling everything that happens to him from the initial Wildfire Global Outbreak until he joins with Rick Grimes's group at that quarry near Atlanta," explained Drew Haworth - creative director with developer Terminal Reality - in a statement.
"And on the way, we'll reveal a couple of our own interesting backstory surprises that fans haven't already gleaned from the series.
"Players will have the opportunity to meet some interesting characters and have a hand in deciding their fate. Oh, and there are some really cool zombies."
Published by Activision, the game does not yet have a release date - although it will be on sale next year.