The Wanted look likely to score their second week at No.1 with dance track, Glad You Came.
According to Official Chart Update figures, the lads are currently fighting off some tough competition from former chart-topper, DJ Fresh and Sian Evans' Louder, which is on course to remain in second place.
The rest of the top ten remains relatively unchanged from last week, with Pitbull, Ne-Yo and Co's Give Me Everything climbing from ninth place to No.6.
Elsewhere in the Official UK Album Chart, Adele is on course to extend her reign at No.1, with Beyoncé's 4, Adele's 19, Lady GaGa's Born This Way and Bruno Mars' Doo-Wops & Hooligans completing the top five.
At the moment, the highest new entry on the album countdown comes from LMFAO and their Sorry For Party Rocking LP, which is on track to make it's chart debut at No.6.
The Official Midweek Singles Chart Update:
1. The Wanted - Glad You Came
2. DJ Fresh Feat. Sian Evans - Louder
3. Ed Sheeran - The A Team
4. Beyoncé - Best Thing I Never Had
5. Loick Essien Feat. Tanya Lacey - How We Roll
6. Pitbull Feat. Ne-Yo, Afrojack & Nayer - Give Me Everything
7. Jason Derulo - Don't Wanna Go Home
8. Calvin Harris Feat. Kelis - Bounce
9. Example - Changed The Way You Kissed Me
10. Katy Perry - Last Friday Night (T.G.I.F)