Commenting on her win, Tulisa - who also appears in an exclusive cover shoot for the publication's June issue - stated: "Thank you so much for voting for me. It’s a true honour and definitely a lovely confidence boost.
"I’m proud of me and I am who I am. I know that I’m marmite and I wouldn’t wanna be anything less or anything more, I’m just myself. The FHM shoot is without a doubt the sexiest thing I’ve ever done."
She continued: "I believe in embracing being sexy but I’m not one to agree with stripping off for the cameras, I like to be more subtle than that as these shots show.
"This is an award that will stay on the mantelpiece probably for the rest of my life.”
Despite topping the chart last year, Rosie Huntington Whiteley failed to make the top ten in 2012, limping in at a disappointing No.18.
Girls Aloud babe Cheryl - who made history in 2010 by becoming the first British woman to win the prestigious accolade for two consecutive years - came second in the poll, while RiRi finished third.
Glamour modelGeorgia Salpa completes the top five - meaning she's the highest new entry.
Salpa said: "People always talk about the 100 Sexiest – girls as well – and to think that you’d actually be in it…! I like Rosie Huntington-Whiteley, she’s amazing, I love her andMegan Fox too, I think she’s really hot.”
Notable exceptions from the 2012 list include both Leona Lewis.
Joe Barnes, Editor of FHM, stated: “The response we’ve had from readers for FHM’s 100 Sexiest has been overwhelming this year – it really shows the enduring power of FHM and the brand’s ability to engage with men in the UK and around the world.
“There are definitely a few surprise omissions and new entries, but it’s fantastic to see such a strong British showing, with three quarters of the top 20 coming from the UK and Ireland."
He added: "Big congratulations go out to Tulisa, who’s had a sensational year, and I’m sure will only go on to bigger and better things over the next 12 months.”
FHM's 100 Sexiest supplement, featuring the hottest women in the world, comes free with the June edition of FHM magazine, on sale now.