Winfrey has secured an exclusive interview with Bobbi, as well as the late singer's brother Gary Houston and sister-in-law and manager, Patricia Houston.
The interview will air March 11 (9pm ET) on OWN, Oprah's cable network, and will be part of the Oprah's Next Chapter series.
According to an OWN news release shared by the LA Times, Bobbi Kristina will share "personal memories of her mom and how she would like the iconic superstar to be remembered."
It was also stated that the family will address the rumours and speculation surrounding Houston's death.
Bobbi Kristina has been at the centre of media attention in light of her mother's tragic passing, with the 18-year old even being rushed to hospital when news of the I Will Always Love You hitmaker's death first broke, where she was treated for stress.
Bobbi's father R&B star Bobby Brown recently commented on his daughter's health shortly after Houston's death, stating: "My daughter Bobbi Kristina is doing much better. We continue to provide love and support to Bobbi Kristina.
"She is dealing with the tragedy of her mother's death and would prefer to do it outside of the public eye. I ask again that our privacy be respected."